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Published on: May 8, 2018
Effectiveness and Safety of Lattice Radiotherapy in Treating Large Volume Tumors: A Systematic Review and
Wei Li1, Meina Piao1, Lijun Zhai1
1Department of Radiation Oncology, The Third People's Hospital of Dalian, Dalian Municipal Cancer Hospital, Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Background:
Lattice radiotherapy (LRT) is a novel spatially fractionated radiotherapy technique specifically designed to treat large tumors more effectively. By alternating high-dose and low-dose regions within the tumor, LRT generates a highly diverse dose distribution.
Aims:
To review recent literature on LRT to determine its therapeutic efficacy, survival outcomes, and adverse event rates in treating large-volume tumors, thereby strengthening the evidence base for clinical application.
Study Design:
Systematic review and meta-analysis.
Methods:
We conducted a meta-analysis of all relevant LRT studies identified in four databases-PubMed, Embase, the Cochrane Library, and Web of Science-from their inception to September 2024. Only full-text articles were considered eligible. This study adhered to the 2020 PRISMA guidelines.
Results:
The meta-analysis included seven single-arm studies comprising 187 patients. The pooled 3-month complete response rate and partial response rate were 36.67% and 42.49%, respectively, while the three-month progressive disease rate was 7.10%. The tumor volume was reduced by 48.95%. According to survival analysis, the pooled 6-month overall survival rate was 79.27%, with a median response time of 4.25 months. The pooled rates of mild and moderate-to-severe adverse events were 19.40% and 3.37%, respectively. LRT has demonstrated high local control rates and a favorable safety profile in managing large-volume tumors.
Conclusion:
This is the first systematic meta-analysis examining the efficacy and safety of LRT in treating large-volume tumors. Although further high-quality studies are needed for validation, LRT exhibits encouraging efficiency and safety in patients with large solid tumors exceeding 5 cm in diameter.
