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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
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Diagnosis and management of reactive infectious mucocutaneous eruption

Nicole Damari1, Abbie Goodman1, Catherine Bridges2

  • 1Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Journal of Hospital Medicine
|July 7, 2025
PubMed

Insights

Reactive infectious mucocutaneous eruption (RIME) is a distinct clinical entity. This review summarizes current best practices for diagnosing and managing RIME, formerly known as Mycoplasma pneumoniae-induced rash and mucositis (MIRM).

Area of Science:

  • Infectious diseases
  • Dermatology
  • Pediatric infectious diseases

Background:

  • Reactive infectious mucocutaneous eruption (RIME) has undergone evolving clinical classification.
  • Previously termed Mycoplasma pneumoniae-induced rash and mucositis (MIRM).
  • Historically considered a variant of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Purpose of the Study:

  • To summarize current understanding of RIME diagnosis.
  • To outline best practices for RIME management.
  • To clarify the distinction between RIME and other mucocutaneous disorders.

Main Methods:

  • Literature review of RIME diagnosis and management.
  • Synthesis of clinical guidelines and expert consensus.
  • Analysis of historical and current case studies.

Main Results:

  • RIME is recognized as a distinct entity separate from Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
  • Key diagnostic criteria for RIME have been established.
  • Evidence-based management strategies for RIME are presented.

Conclusions:

  • Accurate diagnosis of RIME is crucial for appropriate management.
  • Current best practices emphasize early recognition and supportive care.
  • Further research is needed to fully elucidate RIME pathogenesis and optimize treatment.

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