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Chronic rhinosinusitis and cognition: a systematic review and meta-analysis
E Y Gao1, B K J Tan2, K L Chan3
1Department of Otolaryngology "Head and Neck Surgery, Sengkang General Hospital, Singapore;Department of Otolaryngology "Head and Neck Surgery, Singapore General Hospital, Singapore;Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Rhinology
|July 7, 2025
Summary
Chronic rhinosinusitis (CRS) is linked to poorer cognitive function. However, treating CRS may improve processing speed and working memory, suggesting a potential therapeutic link for cognitive health.
Area of Science:
- Neuroscience
- Otolaryngology
- Cognitive Science
Background:
- Emerging clinical evidence suggests a connection between chronic rhinosinusitis (CRS) and cognitive impairments.
- Neuroinflammation, both local and systemic, is hypothesized as a potential mechanism linking CRS to cognitive decline.
Purpose of the Study:
- To systematically evaluate the association between chronic rhinosinusitis (CRS) diagnosis and cognitive function.
- To investigate the impact of CRS treatment on cognitive performance and dementia risk.
Main Methods:
- A comprehensive meta-analysis of studies comparing cognitive function in patients with and without CRS.
- Searched major databases (PubMed, Embase, Scopus) for relevant studies, assessing risk of bias using ROBINS-I/ROBINS-E.
- Employed random-effects models to synthesize data on cognitive scores and dementia prevalence.
Main Results:
- Included 10 studies with 107,610 participants, finding CRS associated with 9% poorer global cognitive function.
- CRS treatment correlated with significant improvements in processing speed (8-9%) and working memory.
- No significant association was observed between CRS and dementia in cross-sectional analyses.
Conclusions:
- Chronic rhinosinusitis negatively impacts global cognitive function.
- Treatment for CRS demonstrates potential to enhance specific cognitive domains like processing speed and working memory.
- Further large-scale longitudinal research is recommended to fully understand the CRS-cognition relationship.
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