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Updated: Sep 16, 2025

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Predictors of Post-TAVR Left Bundle Branch Block: A Systematic Review and Meta-Analysis.

Hossam Alzu'bi¹, Anan Abu Rmilah^2,3, Hisham F Bahmad⁴

¹Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, Florida, USA.

Journal of Cardiovascular Electrophysiology

|July 7, 2025

Summary

Predictors of new left bundle branch block (LBBB) after transcatheter aortic valve replacement (TAVR) were identified. Diabetes, specific valve sizes/types, and anatomical factors increase LBBB risk, aiding early intervention.

Keywords:

TAVR meta‐analysis new‐onset LBBB predictors systematic review transcatheter aortic valve replacement

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Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

Area of Science:

Cardiology
Interventional Cardiology
Cardiac Electrophysiology

Background:

Left bundle branch block (LBBB) is a common complication after transcatheter aortic valve replacement (TAVR).
Post-TAVR LBBB is linked to adverse clinical outcomes.
Predictors for LBBB post-TAVR require further elucidation.

Purpose of the Study:

To systematically review and meta-analyze predictors of new-onset LBBB following TAVR.
To identify patient, electrocardiographic, anatomic, and device-related factors associated with post-TAVR LBBB.

Main Methods:

Systematic literature search of studies reporting post-TAVR LBBB predictors.
Meta-analysis using a random-effects model to calculate risk ratios and mean differences.
Inclusion of 17 studies with 6357 patients.

Main Results:

26.4% of patients developed post-TAVR LBBB.
Predictors of increased LBBB risk include diabetes mellitus, use of 29-mm valves, and Medtronic CoreValve (MCV).
Significant differences observed in interventricular septal thickness, membranous septal length, LVOT diameter, PR interval, and implantation depth.

Conclusions:

Diabetes, specific valve characteristics (29-mm, MCV), decreased septal thickness, shorter septal length, smaller LVOT diameter, deeper implantation, and prolonged PR interval are associated with higher LBBB risk.
Early identification of these predictors can potentially mitigate conduction abnormalities post-TAVR.