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Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

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Temporal ghost imaging for pump-probe X-ray solution scattering.

B R Mobley¹, Kevin E Schmidt¹, R A Kirian¹

¹Department of Physics, Arizona State University, Tempe, AZ 85287, USA.

Acta Crystallographica. Section A, Foundations and Advances

|July 7, 2025

Summary

This summary is machine-generated.

This study introduces a new algorithm to analyze fast biomolecular dynamics using time-resolved X-ray scattering. The method recovers solution scattering profiles from mixed time-point data, improving the study of rapid molecular changes.

Keywords:

Bayesian SAXS X-ray free electron lasers XFELs ghost imaging pump–probe small-angle X-ray scattering

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Area of Science:

Biophysics
Structural Biology
Biochemistry

Background:

Time-resolved X-ray scattering (TR-XRS) is crucial for studying biomolecular dynamics without sample manipulation.
Fast biological processes, like photo-protein excitation, occur on timescales shorter than typical pump-probe pulse durations.
TR-XRS data from a single pulse pair can represent a mixture of temporal information.

Purpose of the Study:

To develop a novel algorithm for recovering time-resolved solution scattering profiles.
To address the challenge of analyzing data from ultrafast dynamic events in biomolecules.
To enable more accurate investigations of rapid biomolecular motions.

Main Methods:

Development of a simple algorithm to deconvolve mixed time-point data.
Leveraging the temporal profiles of pump and probe X-ray beams.
Application of the mathematical framework from ghost imaging principles.

Main Results:

Successful recovery of dynamics from simulated solution scattering data.
Demonstration of the algorithm's ability to extract temporal information from mixed signals.
Validation of the ghost imaging-inspired approach for TR-XRS data analysis.

Conclusions:

The developed algorithm effectively recovers biomolecular dynamics from mixed time-point scattering data.
This method enhances the capability of TR-XRS to study ultrafast processes in solution.
The ghost imaging framework provides a powerful mathematical basis for analyzing complex X-ray scattering dynamics.