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Related Concept Videos

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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
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Innovative Multilayered Electrospun Fiber Systems for Dual-Action HIV Prophylaxis and Nonhormonal Contraception.

Deborah A Ogundemuren1, Peace-Ofonabasi O Bassey1, Karamot O Oyediran1

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Multilayer electrospun fibers deliver tenofovir (TFV) for HIV prevention and nifedipine (NFP) for contraception. This dual-protection system offers on-demand, sustained release for women's health.

Keywords:
CatSper channel blockerelectrospun fibersmultipurpose prevention technologypH-responsive drug releasetenofovir

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Multipurpose prevention technologies (MPTs) are crucial for women's health, addressing HIV/STI risks and contraceptive needs.
  • Electrospun fibers offer a promising platform for on-demand, single-dose protection.
  • Integrating HIV microbicides and contraceptives into one system enhances user adherence and efficacy.

Purpose of the Study:

  • To investigate a multilayer electrospun fiber construct for co-delivery of tenofovir (TFV) and nifedipine (NFP).
  • To achieve pH-responsive release of TFV and sustained release of NFP for dual protection.
  • To evaluate the potential of this system for pre-exposure prophylaxis (PrEP) and contraception.

Main Methods:

  • Fabrication of multilayer electrospun fibers using polycaprolactone (PCL) and cellulose acetate phthalate (CAP).
  • Characterization of fiber morphology, mechanical, and chemical properties.
  • Assessment of mucoadhesion, drug release kinetics, encapsulation efficiency, and safety.

Main Results:

  • High encapsulation efficiencies achieved for both TFV (52.13%) and NFP (63.86%).
  • TFV-loaded CAP layer demonstrated pH-responsive release via Fickian diffusion.
  • NFP-loaded PCL layer exhibited sustained release, approaching zero-order kinetics in specific environments.

Conclusions:

  • Multilayered CAP/PCL electrospun fibers show potential for intravaginal co-delivery of TFV and NFP.
  • This system could provide a novel dual-protection strategy against HIV-1 and unplanned pregnancy.
  • Further development could lead to advanced MPTs for enhanced women's reproductive health.