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Clinical and Radiological Response Following Single-Session Gamma Knife Radiosurgery in Cavernous Sinus Hemangiomas
Ananda Kalgudi1, Abhijit Goyal-Honavar1, Nishanth Sadashiva1
1Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India.
Journal of Neurological Surgery. Part B, Skull Base
|July 7, 2025
Summary
Gamma Knife radiosurgery (GKRS) effectively treats cavernous sinus hemangiomas (CSH), achieving significant tumor volume reduction and clinical improvement. This radiosurgery approach offers a safe alternative to surgery with minimal side effects.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Radiosurgery
Background:
- Cavernous sinus hemangiomas (CSH) are rare tumors, accounting for 2-3% of cavernous sinus lesions.
- Optimal management for CSH remains debated, with options including microsurgical resection and radiosurgery.
- Gamma Knife radiosurgery (GKRS) is increasingly considered for CSH treatment.
Purpose of the Study:
- To evaluate the efficacy and safety of single-session GKRS for both primary and residual CSH.
- To analyze tumor volume reduction and clinical outcomes following GKRS treatment.
- To assess the rate of complete response and neurological improvement after GKRS.
Main Methods:
- Retrospective analysis of 33 patients with CSH treated with GKRS between 2012 and 2021.
- Inclusion of both primary (26 patients) and residual (7 patients) CSH cases.
- Assessment of demographic, clinical, radiological data, and clinicoradiological response post-GKRS.
Main Results:
- Mean tumor volume reduction of 87.6% observed over a median follow-up of 41 months.
- Complete radiological response achieved in 69.7% of patients (23/33).
- Clinical improvement noted in 69.7% of patients, with no reported radiation-induced complications.
Conclusions:
- CSH exhibit a characteristic appearance and predictable response to radiosurgery.
- GKRS is a safe and effective treatment for CSH, yielding high rates of tumor shrinkage and functional improvement.
- GKRS offers a viable alternative to surgical resection, minimizing associated morbidity.
