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Updated: Sep 16, 2025
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
11.6K
High-density lipoprotein cholesterol and multiple sclerosis: a systematic review and meta-analysis
Anastasios Makris1, Nikoletta Palli2, Angelos Liontos3
1School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Summary
Patients with relapsing remitting multiple sclerosis (RRMS) have lower high-density lipoprotein cholesterol (HDL-C) levels compared to healthy individuals. This finding suggests lipid profiles, particularly HDL-C, are important in assessing RRMS disease activity.
Area of Science:
- Neurology
- Metabolic Research
Background:
- Multiple sclerosis (MS) is a chronic central nervous system inflammatory disease.
- Lipid metabolism is increasingly recognized for its association with MS clinical outcomes.
Purpose of the Study:
- To systematically investigate the association between high-density lipoprotein cholesterol (HDL-C) and disease activity in multiple sclerosis (MS).
Main Methods:
- A systematic literature search was conducted across PubMed, Cochrane Library, and Clinicaltrials.gov.
- Qualitative synthesis and meta-analysis of prospective and retrospective studies on HDL-C in MS patients were performed.
- Mean differences in HDL-C between relapsing-remitting MS (RRMS) cases and healthy controls (HC) were analyzed.
Main Results:
- Thirteen studies including 1692 participants (859 RRMS, 833 HC) were analyzed.
- RRMS patients exhibited significantly lower HDL-C levels compared to HC (MD: -3.35 mg/dl, p = 0.005).
- Higher triglycerides and total cholesterol levels were observed in RRMS patients versus HC, while low-density lipoprotein cholesterol showed no significant difference.
Conclusions:
- High-density lipoprotein cholesterol (HDL-C) levels are significantly decreased in patients with relapsing-remitting multiple sclerosis (RRMS) compared to healthy controls.
- Lipid profile parameters, including HDL-C, warrant consideration in the clinical assessment of RRMS patients.
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