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Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Desmosomes01:05

Desmosomes

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

39
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Related Experiment Video

Updated: Sep 16, 2025

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.
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Desmoplakin Cardiomyopathy: Myocarditis-Like Episodes.

Tarek Fatrous1, Sara Ibzea2, Sharafath Hussain Zahir Hussain1

  • 1Medicine, Milton Keynes University Hospital NHS Trust, Milton Keynes, GBR.

Cureus
|July 7, 2025
PubMed
Summary

Desmoplakin cardiomyopathy (DSP) can mimic recurrent myocarditis in young adults. Genetic testing confirmed DSP in a patient with persistent chest pain and cardiac MRI findings, leading to ICD implantation for sudden cardiac death prevention.

Keywords:
cardiomyopathycoviddesmoplakingeneticsmyocarditisvaccine

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Area of Science:

  • Cardiology
  • Genetics
  • Cardiovascular Imaging

Background:

  • Recurrent chest pain in young adults can be misdiagnosed.
  • Myocarditis is a common initial diagnosis for such presentations.

Observation:

  • A 21-year-old woman presented with a 3-year history of recurrent chest pain.
  • Initial symptoms included elevated troponin and myocardial edema on cardiac MRI, suggestive of myocarditis.
  • Serial imaging revealed persistent myocardial scarring without active inflammation despite management.

Findings:

  • Genetic testing identified a heterozygous deletion in the desmoplakin (DSP) gene.
  • This confirmed the diagnosis of desmoplakin cardiomyopathy.
  • Electrocardiogram showed T-wave inversions; a subcutaneous implantable cardioverter-defibrillator (s-ICD) was placed for primary prevention of sudden cardiac death.

Implications:

  • Desmoplakin cardiomyopathy should be considered in the differential diagnosis of recurrent myocarditis-like syndromes.
  • This is particularly relevant in young patients with non-ischaemic cardiac findings and characteristic imaging features.
  • Early diagnosis and risk stratification are crucial for preventing sudden cardiac death in DSP cardiomyopathy.