Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Accessory Structures of the Eye01:17

Accessory Structures of the Eye

1.9K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.9K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

3.9K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
3.9K
Muscles of the Eye01:20

Muscles of the Eye

2.1K
The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
2.1K
Glaucoma: Overview01:25

Glaucoma: Overview

777
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
777
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

7.6K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.6K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.8K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Segmental Outflow and Trabecular Meshwork Stiffness in an Ocular Hypertensive Mouse Model.

Investigative ophthalmology & visual science·2026
Same author

Microtubule stability modulates Schlemm's canal cell mechanobiology and outflow facility in glaucoma.

bioRxiv : the preprint server for biology·2026
Same author

Segmental outflow and trabecular meshwork stiffness in an ocular hypertensive mouse model.

bioRxiv : the preprint server for biology·2026
Same author

Author Response: Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway.

Investigative ophthalmology & visual science·2026
Same author

Endothelial cell stiffness and type drive the formation of biomechanically induced transcellular pores.

Cell reports·2025
Same author

Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway.

Investigative ophthalmology & visual science·2025

Related Experiment Video

Updated: Sep 16, 2025

Author Spotlight: In-Depth Morphometric Examination and Quantification of Native Lens Structure Using Whole Mount Imaging
05:45

Author Spotlight: In-Depth Morphometric Examination and Quantification of Native Lens Structure Using Whole Mount Imaging

Published on: January 19, 2024

1.2K

Mechanobiology in the eye.

C Ross Ethier1,2,3, Samuel Herberg4,5,6,7

  • 1Wallace H. Coulter Dept. of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA USA.

Npj Biological Physics and Mechanics
|July 7, 2025
PubMed
Summary

Ocular mechanobiology, the study of how mechanical forces affect eye cells, is crucial for understanding and treating diseases like glaucoma. Research into these cellular responses may uncover new therapeutic targets for vision loss.

Keywords:
Atomic force microscopyDiseasesMechanisms of disease

More Related Videos

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

10.1K
Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes
05:19

Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes

Published on: April 5, 2024

2.5K

Related Experiment Videos

Last Updated: Sep 16, 2025

Author Spotlight: In-Depth Morphometric Examination and Quantification of Native Lens Structure Using Whole Mount Imaging
05:45

Author Spotlight: In-Depth Morphometric Examination and Quantification of Native Lens Structure Using Whole Mount Imaging

Published on: January 19, 2024

1.2K
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

10.1K
Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes
05:19

Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes

Published on: April 5, 2024

2.5K

Area of Science:

  • Ocular biology
  • Biomedical engineering
  • Cellular mechanobiology

Background:

  • The eye's dynamic environment necessitates highly mechanosensitive and mechanoresponsive ocular cells.
  • Defects in mechanobiological pathways are implicated in sight-threatening ocular diseases.
  • Ocular mechanobiology is vital for understanding tissue function and disease pathogenesis.

Purpose of the Study:

  • To provide an overview of ocular cell mechanobiology in the lens and cornea.
  • To review the role of mechanobiology in glaucoma, a common blinding disease.
  • To highlight the importance of mechanobiology in ocular pathologies.

Main Methods:

  • Review of existing literature on ocular mechanobiology.
  • Analysis of mechanosensory elements and pathways in ocular cells.
  • Focus on the interplay between mechanical stimuli and glaucoma pathology.

Main Results:

  • Mechanobiology is integral to the lens and cornea, with defects linked to disease.
  • Mechanical stimuli significantly influence glaucoma pathology, affecting intraocular pressure regulation and neural cell responses.
  • Glaucoma involves complex mechanosensory and mechanotransducing pathways in anterior and posterior eye cells.

Conclusions:

  • Despite extensive research, the mechanobiology of glaucoma remains incompletely understood.
  • Continued investigation into glaucomatous mechanobiology is essential for identifying novel therapeutic targets.
  • Understanding ocular mechanobiology offers potential for new treatments for challenging eye diseases.