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Radiation-induced brain necrosis during pregnancy: a delayed complication of gestational trophoblastic neoplasia

Harsha Shah1, Jessica Phillips1, Mandish K Dhanjal1

  • 1Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK.

Obstetric Medicine
|July 7, 2025
PubMed

Radiation-induced brain necrosis (RIBN) is a rare but serious delayed complication of intracerebral radiotherapy. We present the case of a 34-year-old woman with a history of gestational trophoblastic neoplasia (GTN) with brain metastases, who presented with symptoms related to RIBN at 20 weeks' gestation in a subsequent pregnancy. These included right homonymous inferior quadrantanopia and headaches. We describe the imaging and diagnostic tests used to assess for GTN recurrence and the specific management of RIBN in pregnancy within a multidisciplinary care setting.

Keywords:
Trophoblastic neoplasmsbrain metastasesneoplasticneurologypregnancy complications

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