Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

6.0K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
6.0K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

92
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
92
Inflammation01:38

Inflammation

55.3K
Overview
55.3K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

40
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
40
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

63
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
63
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

41
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
41

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep and repetitive transcranial magnetic stimulation improves motor dysfunction after basal ganglia infarction: preliminary findings on efficacy and electrophysiological mechanisms.

Frontiers in neuroscience·2026
Same author

Endomorphin analogs CEMR-1 and CEMR-2 administered intravenously display potent antinociception with limited tolerance in acute, neuropathic and inflammatory pain.

Neuropharmacology·2026
Same author

Psychosocial etiology and management of chronic pelvic pain in women: a systematic review.

BMC psychology·2026
Same author

Humic acid and tryptophan prolong virus survival and infectivity: Molecular interactions and mechanisms.

Water research·2026
Same author

Caged xanthones with cytotoxic activity from the leaves and twigs of Garcinia oligantha.

Phytochemistry·2026
Same author

Spatiotemporal analysis of climatic and anthropogenic drivers of winter smog in the Indo-Gangetic Plain with a focus on Lahore.

Environmental science and pollution research international·2026

Related Experiment Video

Updated: Sep 16, 2025

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
07:51

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Published on: January 13, 2012

20.4K

Correction: The cGAS-STING pathway in atherosclerosis.

Si-Yu Wang1,2,3, Yu-Shan Chen1,2, Bo-Yuan Jin1,2,3

  • 1Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.

Frontiers in Cardiovascular Medicine
|July 7, 2025
PubMed
Summary

This study corrects a previously published article's DOI. The correction ensures accurate citation and retrieval of the research findings for cardiovascular research. This improves scientific record integrity.

Keywords:
STING inhibitorsatherosclerosiscGAS inhibitorscGAS-STING pathwayrisk factorstherapeutic potential

More Related Videos

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
11:00

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

28.9K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.3K

Related Experiment Videos

Last Updated: Sep 16, 2025

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
07:51

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Published on: January 13, 2012

20.4K
A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
11:00

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

28.9K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.3K

Area of Science:

  • Cardiovascular medicine and research.

Context:

  • Ensuring the accuracy of scientific literature is crucial for research integrity.
  • Proper citation facilitates the retrieval and verification of scientific findings.
  • Digital Object Identifiers (DOIs) are essential for uniquely identifying scholarly articles.

Purpose:

  • To correct an error in the Digital Object Identifier (DOI) of a published article.
  • To ensure that researchers can accurately access and cite the intended research.
  • To maintain the integrity and reliability of the scientific record in cardiovascular research.

Summary:

  • The article corrects the Digital Object Identifier (DOI) for a previously published work.
  • This correction rectifies a citation error, ensuring the article is correctly linked.
  • The intended article focuses on cardiovascular research, with the DOI now accurately reflecting its content.

Impact:

  • Facilitates accurate citation and retrieval of the corrected article.
  • Enhances the reliability of the scientific literature in the field of cardiovascular research.
  • Supports the broader scientific community by ensuring correct access to research data.