Carfilzomib-Induced Thrombotic Microangiopathy: A Case Report on a Rare Complication

Manogna Pendyala1, Ayesha Tahir1, Purnoor Kaur1

  • 1Department of Internal Medicine, Mercy Health - St. Vincent Medical Center, Toledo, USA.

Cureus
|July 7, 2025
PubMed

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Types of Intermediate Filaments

The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
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