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Carfilzomib-Induced Thrombotic Microangiopathy: A Case Report on a Rare Complication
Manogna Pendyala1, Ayesha Tahir1, Purnoor Kaur1
1Department of Internal Medicine, Mercy Health - St. Vincent Medical Center, Toledo, USA.
Abstract:
Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ injury due to microvascular thrombosis. Drug-induced TMA is a recognized subtype, but its diagnosis is challenging due to the absence of specific laboratory tests to identify the agent. Many chemotherapeutic agents are associated with TMA. Carfilzomib is a newer chemotherapeutic agent and is an uncommon cause of TMA. We report the case of a 71-year-old female patient undergoing treatment with carfilzomib for refractory multiple myeloma who developed suspected carfilzomib-induced TMA and was managed successfully with plasmapheresis and hemodialysis leading to clinical improvement.
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