Oncocytic Features in Choroid Plexus Tumors: An Integrative Clinicopathological Study

Area of Science:

• Neuro-oncology
• Cellular biology
• Tumor pathology

Background:

• Choroid plexus tumors (CPTs) are rare brain neoplasms.
• Limited understanding of oncocytic changes (OCs) and amyloid in CPTs.

Purpose of the Study:

• Investigate the occurrence and biological significance of OCs in CPTs.
• Correlate OCs with clinicopathological features and patient outcomes.

Main Methods:

• Analysis of 42 primary and recurrent CPTs (WHO 2021 classification).
• Histopathological examination for OCs, amyloid, and other features.
• Immunohistochemical staining for various markers (fascin, CD1a, interleukins, TNF-α, HIF-1α).

Main Results:

• OCs observed in 36% of CPP, 38% of ACPP, and 17% of CPC.
• OCs correlated with mortality (p=0.049), necrosis (p=0.014), and hemorrhage (p=0.000).
• Positive reactions for fascin, CD1a, IL-2, IL-6, TNF-α, CD68, and HIF-1α; epithelial cells in CPP/CPC did not react.

Conclusions:

• OCs in CPTs are rare, associated with inflammatory, ischemic, and hypoxic conditions.
• OCs may involve dendritic cells and are linked to ciliary dysfunction.
• Further research is needed to elucidate the role of OCs in CPTs.