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Upregulation of lncRNA ANRASSF1 is associated with the lymph node metastasis and H. pylori infection in gastric cancer

  • 0Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
Biomarkers in Medicine +

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July 7, 2025

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July 7, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Long non-coding RNA ANRASSF1 is overexpressed in gastric cancer (GC) and linked to metastasis and infection. ANRASSF1 may serve as a diagnostic and prognostic biomarker for GC patients.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genetics

Background

  • Gastric cancer (GC) is a prevalent global malignancy.
  • Early GC diagnosis improves survival and treatment efficacy.
  • Investigating novel biomarkers for GC is crucial.

Purpose Of The Study

  • To evaluate the expression of long non-coding RNA (lncRNA) ANRASSF1 in gastric tumor tissues.
  • To determine the potential role of ANRASSF1 as a biomarker in GC.

Main Methods

  • Collected 102 pairs of gastric tumor and non-tumor tissues.
  • Extracted RNA and synthesized cDNA.
  • Quantified ANRASSF1 expression using real-time PCR.

Main Results

  • ANRASSF1 was significantly overexpressed in GC tissues (p < 0.001).
  • Elevated ANRASSF1 expression correlated with lymph node metastasis (p = 0.014).
  • ANRASSF1 levels were associated with Helicobacter pylori infection (p = 0.029) and Lauren subtypes (p = 0.0001).

Conclusions

  • LncRNA ANRASSF1 exhibits an oncogenic role in gastric cancer.
  • ANRASSF1 shows potential as a diagnostic and prognostic biomarker for GC.

Keywords:

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