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Glutamate and Hypoxia as a Stress Model for the Isolated Perfused Vertebrate Retina
Published on: March 22, 2015
The effect of mannitol infusion on retinal function and oxygen tension
Investigative Ophthalmology & Visual Science
|July 1, 1977
Abstract:
Mannitol administered intravenously in rhesus monkeys resulted in a temporary recovery of the visual evoked response (VER) after its decrease due to elevation of the intraocular pressure. Mannitol infusion caused an immediate, albeit transitory, increase in retinal oxygen tension. These changes were independent of the ocular hypotensive effect of mannitol, and we conclude that the drug is a far better agent for the treatment of acute glaucoma than heretofore believed.

