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Matrix Metalloproteinase-9: A Key Diagnostic Biomarker in Cancer Progression.

Arpita Srivastava1, Jatin Gupta1, Shivani Singhal1

  • 1Transcriptome Laboratory, Centre of Excellence in Emerging Diseases, Jaypee Institute of Information Technology, Block A, Industrial Area, Sector 62, Noida, Uttar Pradesh, 201309, India.

Current Drug Targets
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Summary

Matrix metalloproteinase-9 (MMP-9) is a key enzyme in cancer progression and a promising biomarker for early detection. Innovative biosensors are being developed for sensitive MMP-9 detection, aiding cancer diagnosis and targeted therapies.

Keywords:
Matrix metalloproteinasebiomarkerbiomaterialcancerdiagnostics.extracellular matrixsensors

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Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Biomedical Engineering

Background:

  • Matrix metalloproteinase-9 (MMP-9) is an enzyme crucial for extracellular matrix remodeling, implicated in physiological and pathological processes.
  • Overexpression or dysregulation of MMP-9 is linked to cancer development and progression, making it a significant therapeutic target.
  • MMP-9's role in tumorigenesis, including cell migration and angiogenesis, highlights its importance in cancer therapy.

Purpose of the Study:

  • To review the role of MMP-9 as a biomarker in cancer diagnosis and prognosis.
  • To explore the detection of MMP-9 using innovative biosensor technologies.
  • To discuss the translational potential of MMP-9 as a biomarker and therapeutic target in oncology.

Main Methods:

  • Review of existing literature on MMP-9's function in cancer.
  • Analysis of advancements in biosensor technologies for biomarker detection.
  • Examination of clinical trials involving MMP-9 inhibitors.

Main Results:

  • MMP-9 is involved in key cancer processes such as migration, angiogenesis, and apoptosis regulation.
  • Biosensors, both cleavage-based and non-cleavage-based, offer rapid, sensitive, and specific detection of MMP-9.
  • Clinical trials are evaluating MMP-9 inhibitors for halting metastatic spread.

Conclusions:

  • MMP-9 holds significant translational potential as a biomarker for early cancer detection and monitoring.
  • Innovative biosensors can enhance point-of-care diagnostics for cancer.
  • Targeting MMP-9 offers a viable therapeutic strategy to improve patient outcomes in oncology.