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Published on: September 22, 2020

Higher C-reactive protein/albumin ratio is a potential marker for predicting amputation in patients with diabetic

Li Zhang¹, Xufeng Gao², Meifang He¹

¹Department of Endocrinology, Taiyuan City Central Hospital, Taiyuan, Shanxi, China.

Archives of Endocrinology and Metabolism

|July 7, 2025

Abstract

Objective:

Non-traumatic amputation resulting from diabetic foot infection (DFI) poses significant clinical and public health concerns. The C-reactive protein (CRP)/albumin ratio represents a combination of the infection level and nutritional status. This study investigated the relationship between the CRP/albumin ratio and amputation in patients with diabetic foot infections.

Subjects And Methods:

Patients with a DFI of Wagner grade. 3 diagnosed between January 2020 and September 2023 were retrospectively analyzed. The association between the CRP/albumin ratio and amputation was explored using multivariable logistic regression modeling. Stratified analyses were also performed to ensure the reliability of the findings.

Results:

Of 301 enrolled patients, 226 underwent amputation and 75 did not. The amputation rate increased with a greater CRP/albumin ratio in the non-adjusted, minimally adjusted, and fully adjusted models, regardless of whether the CRP/albumin ratio was regarded as a categorical or continuous variable.

Conclusion:

An increased CRP/albumin ratio was associated with a greater risk of amputation in individuals with DFI.

Keywords:

C-reactive protein Diabetic foot infection albumin amputation

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Articles linked to this work by shared authors, journal, and citation graph.

Nonlinear association between C-reactive protein and severity of diabetic foot infection in patients with diabetes: A retrospective cohort study with clinical implications.

PloS one·2025

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