Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

529
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
529
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

218
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
218
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

315
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
315
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

277
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
277
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

219
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
219
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.0K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potassium-competitive acid blockers and proton-pump inhibitors for the healing and maintenance of erosive esophagitis: a comprehensive and updated systematic review with network meta-analysis.

Esophagus : official journal of the Japan Esophageal Society·2026
Same author

Short-Term Daily Vonoprazan Treatment Is More Commonly Associated With Infectious Gastroenteritis Than Short-Term Daily PPI Treatment.

Neurogastroenterology and motility·2026
Same author

Lyon Consensus 2.0: what has changed for GERD diagnosis?

Expert review of gastroenterology & hepatology·2026
Same author

ATP-driven membrane binding and polymerization of bacterial actin MreB promotes local membrane fluidization.

Biophysical journal·2026
Same author

Trends in Utilization of Surgical and Endoscopic Anti-Reflux Procedures in the United States (1995-2024).

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2026
Same author

'It felt like surveillance, not support': understanding barriers to enrolling older adults in an energy-linked digital health study during pandemic recovery and the cost-of-living crisis.

BMC geriatrics·2026

Related Experiment Video

Updated: Sep 16, 2025

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.3K

Gastroesophageal Reflux Disease and Amazon.com.

Richard Wong1, Tomas Navarro-Rodriguez2, Ronnie Fass1

  • 1Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH.

Journal of Clinical Gastroenterology
|July 7, 2025
PubMed
Summary

Many Amazon products for acid reflux (GERD) lack scientific evidence. Only weight loss and specific medications show high evidence; most other treatments are unproven.

Keywords:
Amazon.comgastroesophageal reflux diseasesocial media

More Related Videos

Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver
08:25

Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver

Published on: August 27, 2021

2.7K
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

2.9K

Related Experiment Videos

Last Updated: Sep 16, 2025

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.3K
Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver
08:25

Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver

Published on: August 27, 2021

2.7K
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

2.9K

Area of Science:

  • Gastroenterology
  • Health Informatics
  • Evidence-Based Medicine

Background:

  • Amazon.com is a major online platform for health information and product purchases.
  • Information on e-commerce platforms may be misleading and lack scientific validation.
  • Consumers often rely on such platforms for knowledge about medical conditions like GERD.

Purpose of the Study:

  • To scientifically evaluate Amazon.com's products marketed for GERD treatment.
  • To assess the scientific validity of claims made for these GERD products.

Main Methods:

  • Searched Amazon.com for GERD-related products.
  • Assessed the strength of evidence for medical claims using the AHRQ EPC program criteria.
  • Reviewed published scientific and medical literature.

Main Results:

  • High evidence supports weight loss and specific medications (antacids, H2RAs, PPIs, P-CABs) for GERD.
  • Moderate evidence exists for GERD pillows.
  • Low to insufficient evidence found for teas, supplements, probiotics, apple cider vinegar, and most other non-traditional treatments.

Conclusions:

  • Consumers must critically assess online health information and product claims.
  • Prioritize scientifically validated treatments and consult reliable sources before purchasing GERD products.
  • Be cautious of over-the-counter remedies marketed for medical conditions.