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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
Published on: November 19, 2012
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First-Year Psychiatric Outcome of Pediatric Mild Traumatic Brain Injury: A Prospective Longitudinal Controlled Study
Jeffrey E Max1,2, Nicholas Judd3, Erin D Bigler4,5
1Department of Psychiatry, University of California, San Diego, California, USA.
Journal of Neurotrauma
|July 7, 2025
Summary
Novel psychiatric disorders (NPD) can emerge after mild traumatic brain injury (mTBI) or orthopedic injury (OI). Poorer preinjury family function is a key predictor for developing NPD in the first year post-injury.
Area of Science:
- Pediatric neurology
- Child psychiatry
- Traumatology
Background:
- Novel psychiatric disorders (NPD) are a concern following pediatric injuries.
- Understanding the timeline and predictors of NPD after mild traumatic brain injury (mTBI) and orthopedic injury (OI) is crucial for early intervention.
Purpose of the Study:
- To investigate the occurrence, characteristics, and risk factors of NPD within 12 months post-injury in children aged 8-15.
- To compare NPD development after mTBI versus OI, considering preinjury variables and injury severity.
Main Methods:
- Prospective cohort study of 220 children with mTBI and 110 with OI.
- Semi-structured psychiatric interviews at baseline, 3, 6, and 12 months post-injury.
- Analysis of preinjury child and family variables, and injury severity as predictors of NPD.
Main Results:
- NPD risk increased over time in the orthopedic injury (OI) group, but not in the mild traumatic brain injury (mTBI) group, indicating an earlier onset of effects in mTBI.
- Poorer preinjury family function and preinjury psychiatric disorder were associated with higher NPD risk.
- Preinjury family function was the primary predictor of NPD in the first year after mTBI and OI.
Conclusions:
- Both mTBI and OI can lead to similar psychiatric outcomes in the first year, but the onset of adverse effects is earlier following mTBI.
- Preinjury family function is a significant predictor for the development of NPD after both types of injuries.

