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Enamel thickness in 47,XYY males' permanent teeth
Annals of Human Biology
|September 1, 1985
Summary
Males with 47,XYY syndrome have thicker tooth enamel and dentin. The Y chromosome appears to promote tooth growth, influencing enamel formation and dentin development.
Area of Science:
- Human genetics
- Dental anthropology
- Endocrinology
Background:
- The Y chromosome's role in growth is not fully understood.
- Previous studies suggest a growth-promoting effect of the Y chromosome on tooth development.
Purpose of the Study:
- To investigate enamel and dentin thickness in individuals with 47,XYY syndrome.
- To explore the Y chromosome's influence on tooth size and growth.
Main Methods:
- Radiographic determination of enamel and dentin thickness.
- Comparison of measurements between 47,XYY males, relatives, and controls.
- Analysis of tooth size in males with Y chromosome deletions.
Main Results:
- Individuals with 47,XYY syndrome exhibited increased enamel and dentin thickness compared to controls.
- Evidence suggests specific growth-promoting genes on the Y chromosome's long arm.
- The Y chromosome's influence on amelogenesis appears regulatory.
Conclusions:
- The Y chromosome plays a role in regulating tooth growth and size.
- Differential growth effects of Y and X chromosomes may explain sex-based tooth size differences.
- Findings support the Y chromosome's direct impact on enamel and dentin formation.