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Multiscale, interspecies evaluation of parameters affecting alveolar bone repair
Pavla Ticha1,2, Arush Joshi1, Julia S Dworan1,3
1Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford School of Medicine, Stanford University, Stanford, California, USA.
Journal of Periodontology
|July 7, 2025
Summary
Bone healing processes in the craniomaxillofacial skeleton are conserved across species, from rodents to minipigs. This suggests rodents are excellent models for preclinical bone repair research.
Area of Science:
- Comparative biology
- Skeletal biology
- Regenerative medicine
Background:
- Craniomaxillofacial (CMF) bone healing and remodeling processes vary across species.
- Understanding interspecies differences can improve research value and treatment strategies.
Purpose of the Study:
- To comparatively analyze bone healing in the CMF skeleton across different species.
- To determine the conservation of bone repair and remodeling mechanisms.
Main Methods:
- Osteotomy created in equivalent anatomical locations in mice, rats, minipigs, and humans.
- Quantitative analyses using micro-computed tomography (µCT), histology, histomorphometry, immunohistochemistry, and cellular assays.
Main Results:
- Bone repair programs were highly conserved between rodents and minipigs, correlating with limited human data.
- CMF bone repair in minipigs was equivalent to rodents at later time points.
- Interspecies comparison of healing rates was limited by human tissue time points.
Conclusions:
- Molecular and cellular features of bone repair are shared among mammals, indicating a common healing mechanism.
- Rodents are suitable models for preclinical testing of bone repair strategies due to conserved mechanisms and available research tools.
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