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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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The Emerging Role of Lactate and Lactylation Modifications in the Pathophysiology of Atherosclerotic Cardiovascular

Xianqiong Lu1,2, Qiyuan Luo3, Danfeng Yu2

  • 1Clinical Trials Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550000, China.

Cardiovascular Drugs and Therapy
|July 7, 2025
PubMed

Insights

Lactate and lactylation, linked to glycolysis, are increasingly recognized for their roles in atherosclerosis, a major cause of heart disease and stroke. This review explores their mechanisms and potential as therapeutic targets.

Area of Science:

  • Cardiovascular Science
  • Metabolic Regulation
  • Molecular Biology

Background:

  • Atherosclerosis involves arterial wall lipid accumulation and inflammation, leading to heart disease and stroke.
  • Aging trends are increasing atherosclerosis prevalence globally.
  • Lactate, a glycolysis byproduct, influences cell signaling, inflammation, and metabolism.

Purpose of the Study:

  • To review recent research on lactate and lactylation in atherosclerotic cardiovascular diseases.
  • To explore the mechanisms of lactate and lactylation in atherosclerosis pathogenesis.
  • To analyze their potential as biomarkers and therapeutic targets.

Main Methods:

  • Literature review of current research on lactate and lactylation in atherosclerosis.
  • Analysis of molecular mechanisms including inflammation, oxidative stress, and apoptosis.
  • Evaluation of potential diagnostic and therapeutic applications.

Main Results:

  • Lactate and lactylation play significant roles in the inflammatory and metabolic processes of atherosclerosis.
  • These molecules are implicated in key pathological pathways like oxidative stress and apoptosis.
  • Emerging evidence suggests their utility as potential biomarkers and therapeutic targets.

Conclusions:

  • Lactate and lactylation are critical players in atherosclerotic cardiovascular diseases.
  • Further research is warranted to fully elucidate their roles and therapeutic potential.
  • Understanding lactate's impact offers new avenues for managing atherosclerosis.

Keywords:
AtherosclerosisCardiovascular diseaseLactateLactylation modification

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