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A 3D In Vitro Blood-Brain Barrier Model to Study Pathogen and Drug Effects on the BBB
Alizé Proust1, Robert J Wilkinson2,3,4
1The Francis Crick Institute, London, UK. alize.proust@crick.ac.uk.
Methods in Molecular Biology (Clifton, N.J.)
|July 7, 2025
Abstract:
In vitro blood-brain barrier models play a pivotal role in neuroscience research to study the intricate structure and function of the blood-brain barrier, facilitating drug development, enhancing disease understanding, and advancing treatment strategies for neurological disorders. Here, we present a triple contact coculture model with endothelial cells, astrocytes, and pericytes and offer a physiologically relevant BBB.
