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Association between inflammatory burden index and prognosis in patients with coronary heart disease: A retrospective

Wen Lu1, Xiaoqin Liao2,3, Yan Jiang1

  • 1School of Nursing, Fujian Medical University, Fuzhou, Fujian, China.

Plos One
|July 7, 2025
PubMed

Insights

The inflammatory burden index (IBI) is a novel biomarker indicating higher risks for adverse outcomes in coronary heart disease (CHD) patients. Higher IBI levels are linked to increased major adverse cardiovascular and cerebrovascular events (MACCEs).

Area of Science:

  • Cardiology
  • Biomarkers
  • Systemic Inflammation

Background:

  • Systemic inflammation is a significant factor in the adverse prognosis of coronary heart disease (CHD).
  • The inflammatory burden index (IBI) is a novel biomarker reflecting systemic inflammation.
  • Investigating the association between IBI and CHD patient prognosis is crucial.

Purpose of the Study:

  • To investigate the association between the inflammatory burden index (IBI) and the prognosis of coronary heart disease (CHD) patients.
  • To determine if IBI can predict adverse cardiovascular and cerebrovascular events (MACCEs) in CHD patients.
  • To explore the relationship between IBI levels and specific adverse outcomes like new-onset atrial fibrillation (NOAF) and contrast-induced nephropathy (CIN).

Main Methods:

  • Retrospective analysis of 2453 CHD patients from December 2017 to December 2022.
  • IBI calculated as neutrophil/lymphocyte*C-reactive protein, with patients grouped by baseline IBI quartiles.
  • Multivariate logistic regression and restricted cubic spline (RCS) analysis used to assess IBI's predictive value for MACCEs, NOAF, and CIN.

Main Results:

  • Higher IBI levels, particularly IBI ≥ 45.68, were associated with an increased risk of MACCEs.
  • Baseline IBI independently predicted new-onset atrial fibrillation (NOAF) (OR: 2.05) and contrast-induced nephropathy (CIN) (OR: 1.95) in CHD patients.
  • RCS analysis confirmed a linear relationship between IBI and NOAF, and a nonlinear relationship with CIN.

Conclusions:

  • The inflammatory burden index (IBI) is a promising biomarker for systemic inflammation in CHD patients.
  • Elevated IBI levels are associated with an adverse prognosis and increased risk of MACCEs.
  • These findings support the use of IBI for precise clinical decision-making to improve CHD patient outcomes.
Abstract

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