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Related Experiment Video

Updated: Jun 27, 2026

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

Layers of the monkey visual cortex are selectively modulated during electrical stimulation.

Sangjun Lee¹, Zhihe Zhao¹, Ivan Alekseichuk^1,2

¹Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.

|July 7, 2025

Summary

Electrical brain stimulation selectively impacts deeper cortical layers, not superficial ones, affecting neural activity phase-dependently. This finding advances targeted neuromodulation strategies for brain circuits.

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Area of Science:

Neuroscience
Computational Neuroscience

Background:

The mammalian neocortex has six distinct cellular layers crucial for sensory processing.
Laminar recordings of local field potentials (LFPs) are vital for studying neural activity within cortical layers.
Layer-specific effects of electric brain stimulation on LFPs are not well understood.

Purpose of the Study:

To investigate the layer-specific effects of electric stimulation on LFPs in the primary visual cortex.
To determine how electrical stimulation modulates visual-evoked potentials in different cortical layers.

Main Methods:

Recorded laminar LFPs from capuchin monkeys' primary visual cortex during visual stimulation.
Applied low-frequency sinusoidal electric current to the occipital lobe.
Analyzed phase-dependent modulation of visual-evoked potentials relative to electric stimulation.

Main Results:

Deeper cortical layers exhibited phase-dependent changes in LFPs relative to electric stimulation.
Superficial cortical layers did not show significant phase-dependent LFP changes.
A cortical column model supported these findings, attributing them to deeper layer neuronal driving forces.

Conclusions:

Electrical stimulation selectively modulates deeper cortical layers.
Findings provide insight into targeted neuromodulation of specific cortical layers.
This research advances understanding for more precise brain stimulation applications.