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Ethnoracial and Geographic Disparities in Global Atopic Dermatitis Clinical Trials: An Update
Caitlyn B Dagenet1, Sahar Davoudi1, Kyla N Price2
1University of Arizona College of Medicine, Tucson, Arizona, USA.
Introduction:
Atopic dermatitis (AD) disproportionally impacts skin of color (SOC) patients, particularly black/African American children. The number of global AD clinical trials is growing exponentially as the AD medication pipeline expands. Thus, we aimed to provide an analysis of racial, ethnic, and geographical disparities in global AD trials.
Methods:
Race, ethnicity, and location data were extracted from phase 2 and 3 randomized, double-blind, placebo-controlled trials investigating AD therapies from July 2019 to December 2023 on
Results:
Twenty-four completed, randomized controlled trials (RCTs) met the search criteria. North America hosted the highest percentage of RCTs. The majority of participants were white, followed by Asian, and black/African American.
Conclusion:
Despite growing awareness of how AD affects SOC patients, the majority of participants in AD clinical trials are still white. Further efforts to increase reporting and enrollment of diverse participants are critical to further improving clinical trial participant diversity.
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