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Updated: Sep 16, 2025

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
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Cellular senescence and other age-related mechanisms in skeletal diseases

Ke Li1,2, Sihan Hu3,4, Hao Chen5,6

  • 1Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, PR China.

Bone Research
|July 7, 2025
PubMed

Insights

Cellular senescence and its secretory phenotype (SASP) drive skeletal diseases. Targeting senescent cells offers a promising therapeutic strategy for bone regeneration and combating age-related bone conditions.

Area of Science:

  • Gerontology and Regenerative Medicine
  • Skeletal Biology and Disease

Background:

  • Cellular senescence and the senescence-associated secretory phenotype (SASP) are key drivers in skeletal disease development.
  • Age-related changes, including cellular dysfunction and impaired tissue repair, exacerbate skeletal pathologies.

Purpose of the Study:

  • To review the role of cellular senescence and other aging mechanisms in skeletal diseases.
  • To identify potential therapeutic targets for anti-aging interventions in the skeletal system.

Main Methods:

  • Comprehensive literature review of cellular senescence and aging in skeletal diseases.
  • Analysis of mechanisms contributing to age-related skeletal decline.

Main Results:

  • Cellular senescence and SASP significantly contribute to osteoporosis, osteoarthritis, and other skeletal disorders.
  • Targeting senescent cells shows potential for reversing skeletal aging and promoting bone regeneration.

Conclusions:

  • Cellular senescence is a critical factor in age-related skeletal diseases.
  • Therapeutic strategies aimed at senescent cells and aging mechanisms hold promise for skeletal health.

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