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Analysis of frailty change trajectories and its risk factors in patients with gastrointestinal tumor surgery: a prospective observational longitudinal study

  • 0Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
World Journal of Surgical Oncology +

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July 7, 2025

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July 7, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Older patients undergoing gastrointestinal tumor surgery experience dynamic frailty changes. Preoperative frailty, comorbidities, and delayed ambulation predict poor post-surgery outcomes, requiring targeted rehabilitation.

Area Of Science

  • Gerontology
  • Surgical Oncology
  • Clinical Medicine

Background

  • Frailty is a dynamic process, but its post-surgical changes remain unclear.
  • Understanding frailty trajectories after gastrointestinal tumor surgery is crucial for older adults.

Purpose Of The Study

  • To investigate frailty change trajectories in older patients undergoing gastrointestinal tumor surgery.
  • To identify risk factors associated with these frailty trajectories.

Main Methods

  • The Frail Scale (FS) was used to assess frailty from pre-operation to 180 days post-surgery.
  • Latent class analysis (LCA) identified frailty trajectory groups and their associated risk factors.
  • Changes in FS components were systematically recorded and analyzed.

Main Results

  • Four distinct frailty trajectory groups were identified among 212 elderly patients.
  • Significant differences in demographic, clinical, and functional factors were observed across groups.
  • Comorbidities, metabolic equivalent (MET), preoperative frailty, age, time to ambulation, and 6-minute walk test (6MWT) independently influenced frailty trajectories.

Conclusions

  • Frailty is a dynamic process significantly impacted by gastrointestinal tumor surgery.
  • Older patients with higher comorbidity burden, lower functional status (MET, 6MWT), preoperative frailty, and delayed ambulation are at higher risk of persistent or new-onset frailty.
  • These findings highlight the need for clinical attention and tailored rehabilitation programs for vulnerable surgical patients.

Keywords:

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