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Updated: Sep 16, 2025
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Epidemiological characteristics and genotype distribution of human papillomavirus infection in Yangpu district,
Zien Cheng1, Yu Zhao1, Ting Xu1
1Medical Laboratory, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, 200438, China.
Objective:
To analyze the positive rate and genotype distribution of human papillomavirus (HPV) infection in Yangpu District, Shanghai, and to provide a scientific basis for the prevention and treatment of cervical cancer and related diseases.
Methods:
A retrospective analysis was conducted on HPV genotyping data from 19,142 outpatients, inpatients, and health examinees at Shanghai Shidong Hospital from 2020 to 2024. Overall infection rate, genotype distribution, age-specific positivity, and annual trends were evaluated.
Results:
Among 19,142 specimens, 4,421 tested positive for HPV, yielding a total positive rate of 23.10%. The top five prevalent genotypes were HPV-52 (21.72%), HPV-53 (11.94%), HPV-58 (10.19%), HPV-51 (8.02%), and HPV-39 (6.86%). Dominant genotypes varied across years. Age-specific infection rates followed an approximate U-shaped curve, with peaks in the ≤ 20-year group (57.69%) and the 61-70-year group (29.72%). Among mixed infections (28.70% of positives), single infections predominated (71.30%). The most common co-infection combinations were HPV-52 + HPV-53 and HPV-52 + HPV-58. High-risk age groups for HPV infection were 31-40, 51-60, and 61-70 years.
Conclusion:
The HPV infection rate in Yangpu District, Shanghai, was 23.10%, primarily driven by single-genotype infections. HPV-52, -53, and - 58 were the dominant genotypes, with significant age-specific variations. These findings underscore the need for enhanced HPV vaccination promotion and targeted preventive strategies.
