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Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
Published on: September 11, 2013
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Hyaluronic Acid Hydrogel as a Retinal Patch in the Treatment of Rhegmatogenous Retinal Detachment: A Multicenter
Boshi Liu1, Manqiao Wang1, Liangzhang Tan1
1Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Clinical & Experimental Ophthalmology
|July 8, 2025
Summary
A new sodium hyaluronic acid (HA) hydrogel patch shows comparable efficacy to gas tamponade for rhegmatogenous retinal detachment (RRD) treatment. This HA hydrogel offers a favorable safety profile and eliminates the need for prone positioning, enhancing patient comfort.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Regenerative Medicine
Background:
- Rhegmatogenous retinal detachment (RRD) is a serious condition requiring prompt surgical intervention.
- Traditional treatments often involve gas tamponade, necessitating specific postoperative patient positioning.
- Exploring novel biomaterials for retinal tamponade is crucial for improving treatment outcomes and patient experience.
Purpose of the Study:
- To evaluate the efficacy and safety of a linearly cross-linked sodium hyaluronic acid (HA) hydrogel as a retinal patch for RRD treatment.
- To compare the outcomes of HA hydrogel tamponade with traditional perfluoropropane gas (C3F8) tamponade.
- To assess the impact of HA hydrogel on postoperative patient comfort and quality of life.
Main Methods:
- A multicenter, randomized, parallel-controlled trial was conducted with 313 participants diagnosed with RRD (PVR grade A or B).
- Participants received laser photocoagulation followed by intraocular tamponade with either HA hydrogel and air or C3F8 gas.
- The primary outcome was the retinal reattachment rate at 24 weeks, with secondary outcomes including visual acuity, intraocular pressure, and complications.
Main Results:
- Retinal reattachment rates were similar between the HA hydrogel group (91.8%) and the C3F8 gas group (91.4%) at 24 weeks (p=0.903).
- No significant differences were observed in best-corrected visual acuity (BCVA), intraocular pressure (IOP), or postoperative complications between the groups.
- The HA hydrogel group did not require postoperative prone positioning.
Conclusions:
- Linearly cross-linked sodium HA hydrogel is an effective and safe alternative to gas tamponade for RRD treatment.
- This HA hydrogel patch obviates the need for prone positioning, significantly improving postoperative patient comfort and quality of life.
- The study supports the use of HA hydrogel as a promising biomaterial in ophthalmic surgery.
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