Related Experiment Video
Updated: Aug 7, 2026

The Synergistic Effect of Visible Light and Gentamycin on Pseudomona aeruginosa Microorganisms
Published on: July 2, 2013
Peptide-Enhanced Bioactive Hydrogel Combined with Photodynamic-Phage Synergistic Antibacterial Therapy System
Liang Quan1,2, Yuan Xin1,2, Zhiling Zhang1,2
1College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.
Abstract:
Bacterial resistance poses a serious clinical challenge. This study designs a peptide-enhanced bioactive hydrogel with a photodynamic-phage synergistic antibacterial effect that is an efficient antibacterial and promotes wound healing. LaFeO3@C3N4 is characterized with XRD, XPS, SEM, and UV-vis, and the photodynamic properties of LaFeO3@C3N4 producing ROS are confirmed by EPR. The peptide QHREDGS-modified boronate ester hydrogel is characterized by FT-IR, 1HNMR, SEM, dynamic mechanical analysis, etc. Combined LaFeO3@C3N4 and phage phipa10, the peptide QHREDGS-modified boronate ester hydrogel shows synergistic antibacterial and wound healing effects in both in vitro and in vivo experiments. Moreover, the molecular mechanism of tissue regeneration is explored by transcriptomic and protein expression analysis, and the results show that the peptide-enhanced bioactive hydrogel combined with photodynamic-phage synergistic antibacterial therapy system (QBC@DP-P-phi) significantly promoted cell proliferation and migration by regulating key signaling pathways such as PI3K-Akt, VEGF, and MAPK. Overall, this novel hydrogel is promising for the clinical treatment of infected wounds.
More Related Videos
Related Concept Videos
Defense Mechanism Against Infection
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Special Staining Techniques
Biological Methods for Microbial Control
Antimicrobial Effectiveness

