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Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems
Published on: July 4, 2011
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Advances in microneedle-based transdermal fluorescent sensors
Saijin Huang1, Wenxing Gao1, Li Shang1
1State Key Laboratory of Solidification Processing, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an, 710072, China. li.shang@nwpu.edu.cn.
Chemical Communications (Cambridge, England)
|July 8, 2025
Summary
Microneedles (MNs) integrated with fluorescent probes offer sensitive, high-resolution transdermal biomarker detection. This review covers MN sensor types and sensing strategies for detecting various biomarkers, highlighting future diagnostic potential.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Nanotechnology
Background:
- Microneedles (MNs) provide minimally invasive access to interstitial fluid.
- Fluorescent probes integrated with MNs enable sensitive transdermal biomarker detection.
- MN-based sensors offer high sensitivity and spatial resolution for diagnostics.
Purpose of the Study:
- To classify MN-based transdermal fluorescent sensors.
- To review sensing strategies for biomarker detection using MNs.
- To discuss recent progress and future directions in MN-based biosensing.
Main Methods:
- Classification of MN sensors into porous, dissolving, and non-dissolving types.
- Categorization of sensing strategies into probe-loaded, probe-fixed, and probe-released.
- Review of recent advancements in detecting nucleic acids, metal ions, proteins, and metabolites.
Main Results:
- MN-based fluorescent sensors demonstrate excellent analytical performance.
- Visual signal output facilitates multiplexed detection and responsive biosensing.
- Progress has been made in detecting a wide range of biomarkers.
Conclusions:
- MN-based fluorescent sensors hold significant potential for next-generation diagnostics.
- Challenges include signal stability, fabrication scalability, and continuous monitoring.
- Future research should focus on overcoming these challenges for broader biomedical applications.
