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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
The Application of N-Aryl Glycines and Their Analogues in Visible-Light-Promoted Photoredox Catalysis
Jian Wei1, Hongjian Yang2, Qidi He1
1Guangzhou Quality Supervision and Testing Institute, Innovation Center for NQI-Quality Safety of Guangzhou, Guangzhou, 510000, China.
Abstract:
The aminomethylation reaction, a fundamental and versatile organic transformation is extensively utilized to incorporate an aminomethyl group into target molecules and plays a significant role in the synthesis of natural products and functional molecules. In recent years, N-Aryl glycines and their analogues have been widely explored in visible-light-promoted photoredox reactions to install an aminomethyl moiety or construct various N-heterocycles under mild conditions. Their key reaction intermediates are α-aminoalkyl radicals, imines, or iminium ions. Recent advances in this field have been summarized into five categories according to the proposed reaction mechanisms: (i) radical addition initiated aminomethylation reactions, (ii) radical-radical cross coupling reactions, (iii) radical-triggered annulation reactions, (iv) transformations involving imines, and (v) metallophotoredox dual catalysis. We hope this review will give an overview of visible-light-promoted photoredox reactions of N-aryl glycines and their analogues and drive further research progress in this area.
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