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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
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Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Pharmacovigilance01:19

Pharmacovigilance

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
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Microfluidics in Assessing Platelet Function
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Ticagrelor-Induced Dermatological Hypersensitivity Reaction.

Snehal Lunge1, Shimoni R Doshi2, Vidyadhar R Sardesai2

  • 1Dermatology, Bharati Vidyapeeth Medical College, Pune, Pune, IND.

Cureus
|July 8, 2025
PubMed
Summary

Ticagrelor, an antiplatelet drug, can rarely cause skin rashes. This case report details a patient who developed a rash after starting ticagrelor, which resolved after stopping the medication.

Keywords:
: acute coronary syndromeantiplatelet agentsclopidogreldrug-induced rashticagrelor hypersensitivity

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Area of Science:

  • Cardiology
  • Dermatology
  • Pharmacology

Background:

  • Ticagrelor is a P2Y12 inhibitor commonly prescribed for acute coronary syndromes (ACS).
  • While generally safe and effective compared to clopidogrel, rare adverse events require attention.
  • Skin-related side effects of ticagrelor are infrequently documented.

Observation:

  • A 64-year-old male with coronary artery disease developed a diffuse erythematous rash.
  • The rash appeared two days after initiating ticagrelor post-percutaneous coronary intervention.
  • The patient had no prior history of similar reactions.

Findings:

  • The observed rash was consistent with a drug-induced hypersensitivity reaction.
  • Discontinuation of ticagrelor led to the resolution of the skin eruption.
  • Switching to clopidogrel, along with corticosteroids and antihistamines, facilitated recovery.

Implications:

  • This case underscores the importance of considering ticagrelor as a potential cause of dermatological adverse events.
  • Clinicians should be vigilant for skin reactions in patients treated with ticagrelor.
  • Prompt recognition and management of these reactions are crucial for patient safety.