Silent Threats to the Liver: Acute Hepatotoxicity Attributed to Selective Androgen Receptor Modulators (SARMs)

Selective androgen receptor modulators (SARMs) have garnered significant attention in recent years due to their potential to improve muscle mass and athletic performance with reduced androgenic side effects compared to traditional anabolic steroids. However, despite their growing popularity, there is increasing evidence linking SARMs to acute liver injury, raising concerns regarding their safety profile. SARMs can disrupt normal liver function through various pathways, including oxidative stress, alterations in lipid metabolism, and direct hepatocellular toxicity. This article explores the association between SARMs and acute liver injury, examining the mechanisms of hepatotoxicity, clinical manifestations, and potential therapeutic approaches. The findings underscore the need for further research and regulatory oversight in using SARMs, particularly in non-medical and performance-enhancing contexts.