Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications
Merve Kulbay1, Kevin Y Wu2, Doanh Truong3
1Department of Ophthalmology & Visual Sciences McGill University Montréal Quebec Canada.
Smart Molecules : Open Access
|July 8, 2025
Summary
Smart hydrogels offer innovative solutions for various ophthalmic applications, including drug delivery and contact lenses. This review highlights their potential to revolutionize eye treatments and identifies future research directions.
Area of Science:
- Biomaterials Science
- Ophthalmology
- Polymer Chemistry
Background:
- Hydrogels are versatile smart molecules with tunable properties.
- Ophthalmology faces challenges in drug delivery and tissue regeneration.
- Smart hydrogels present novel solutions for ocular conditions.
Purpose of the Study:
- To comprehensively review hydrogels in ophthalmology.
- To explore synthesis, properties, and applications of hydrogels.
- To identify challenges and future research directions for clinical translation.
Main Methods:
- Extensive literature review (2017-2023).
- Analysis of hydrogel properties, synthesis, and responsive capabilities.
- Evaluation of hydrogel applications in ophthalmology.
Main Results:
- Hydrogels show promise in topical/intravitreal drug delivery, contact lenses, ocular adhesives, vitreous substitutes, and cell therapy.
- Comparative analysis indicates advantages over traditional treatments.
- Identified constraints and knowledge gaps for clinical translation.
Conclusions:
- Hydrogels offer significant potential for advancing ophthalmic treatments.
- Further research is needed to overcome translation challenges.
- Hydrogels are poised to transform clinical ophthalmology practices.
