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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
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Hypoxia01:23

Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
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Normobaric Hyperoxia Therapy in Treating Stroke.

Yanli Duan1, Xiangyu Li2, Song Han1

  • 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Clinical Interventions in Aging
|July 8, 2025
PubMed
Summary
This summary is machine-generated.

Normobaric hyperoxia (NBO) enhances neuroprotection in stroke by increasing brain oxygen. It is most effective when combined with reperfusion therapies and specific medications for eligible patients with penumbra or hypoxic brain tissue.

Keywords:
hemorrhagic strokeischemic strokenormobaric hyperoxiapenumbra

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Critical Care Medicine

Background:

  • Normobaric hyperoxia (NBO) is a standard oxygenation therapy for stroke.
  • Its neuroprotective mechanisms in various stroke types require further elucidation.
  • Optimizing NBO treatment is crucial for clinical benefit.

Purpose of the Study:

  • To review the neuroprotective mechanisms of NBO in acute ischemic stroke (AIS), intracranial hemorrhage, and chronic cerebral ischemia.
  • To evaluate NBO's efficacy when combined with other therapies.
  • To identify optimal patient selection criteria for NBO therapy.

Main Methods:

  • Literature review of studies on NBO in stroke models and clinical trials.
  • Analysis of NBO's effects on brain oxygen partial pressure (PaO2).
  • Examination of molecular pathways and cellular responses to NBO.

Main Results:

  • NBO increases brain tissue oxygenation, activating protective molecular pathways.
  • NBO preconditioning and postconditioning confer neuroprotection, particularly with reperfusion.
  • NBO enhances recanalization therapies and shows promise with adjunct medications.

Conclusions:

  • NBO is a safe and effective stroke therapy, especially for patients with penumbra or hypoxic tissue.
  • Reperfusion is critical for NBO's beneficial effects in acute ischemic stroke.
  • Combination therapies and careful patient selection can optimize NBO outcomes.