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Non-coding RNAs as key regulators in hepatitis B virus-related hepatocellular carcinoma

  • 0Protein Engineering Lab, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Frontiers in Immunology +

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July 8, 2025

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July 8, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Non-coding RNAs (ncRNAs) are key players in Hepatitis B virus (HBV)-induced liver cancer (HCC) development. These molecules show promise as diagnostic biomarkers and therapeutic targets for HBV-related HCC.

Area Of Science

  • Molecular Biology
  • Oncology
  • Hepatology

Background

  • Hepatocellular carcinoma (HCC) linked to Hepatitis B virus (HBV) infection is a major global health concern with limited treatment options.
  • Non-coding RNAs (ncRNAs) are increasingly recognized for their regulatory roles in cancer development, including HBV-induced oncogenesis.

Purpose Of The Study

  • To review the diverse types and regulatory mechanisms of ncRNAs involved in HBV-related HCC.
  • To highlight the potential of ncRNAs as diagnostic biomarkers and therapeutic targets for HBV-HCC.
  • To discuss emerging ncRNA-based strategies for improving patient outcomes in HBV-HCC.

Main Methods

  • Comprehensive literature review of studies investigating ncRNAs in the context of HBV-related HCC.
  • Analysis of the roles of various ncRNA classes (microRNAs, long ncRNAs, circular RNAs, small nucleolar RNAs) in cancer hallmarks.
  • Evaluation of the diagnostic and prognostic potential of ncRNAs based on their stability and detectability in biological fluids.

Main Results

  • ncRNAs significantly influence HBV-induced oncogenesis by modulating key cancer hallmarks and promoting HCC progression.
  • ncRNAs exhibit dual roles, acting as both oncogenes and tumor suppressors in HBV-related HCC.
  • The stability and specific expression patterns of ncRNAs in bodily fluids make them promising biomarkers for early detection and prognosis of HBV-HCC.

Conclusions

  • ncRNAs are critical regulators in the pathogenesis of HBV-related HCC.
  • ncRNAs hold significant potential as non-invasive diagnostic markers and novel therapeutic targets for HBV-HCC.
  • Further research into ncRNA-based approaches is crucial for advancing the treatment and management of this malignancy.

Keywords:

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