Cutaneous Reactions to Iron Infusions: A Case Report and Clinical Review

Area of Science:

• Hematology
• Dermatology
• Pharmacology

Background:

• Anemia is a global health concern requiring effective treatments.
• Intravenous (IV) iron formulations are widely used for anemia management due to their efficacy and safety.
• Common IV iron products include iron sucrose, iron dextran, ferric carboxymaltose, ferric derisomaltose, and ferumoxytol.

Purpose of the Study:

• To report an uncommon case of cutaneous hypersensitivity reaction after IV iron administration.
• To review the literature on cutaneous reactions associated with IV iron therapy.
• To emphasize the importance of patient education and staff vigilance regarding these reactions.

Main Methods:

• Case report of a patient experiencing a cutaneous hypersensitivity reaction post-IV iron.
• Comprehensive literature review of documented cutaneous reactions to IV iron formulations.
• Analysis of reaction types, timing, and management strategies.

Main Results:

• The reported case involved an uncommon cutaneous hypersensitivity reaction following IV iron.
• Literature review confirmed that acute and delayed cutaneous reactions are rare but possible adverse events.
• These cutaneous reactions generally respond well to appropriate management strategies.

Conclusions:

• While IV iron is generally safe and effective for anemia, vigilance for rare cutaneous hypersensitivity reactions is necessary.
• Healthcare providers should educate patients about potential skin reactions.
• Prompt recognition and management are crucial for addressing these uncommon adverse events.