Research trends of protein palmitoylation in cancer from 2004 to 2024: a bibliometric and visualization analysis
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Summary
This summary is machine-generated.Protein palmitoylation is increasingly studied in cancer research. This bibliometric analysis of 685 papers reveals a growing focus on its role in tumor immune evasion, metabolic reprogramming, and therapeutic strategies.
Area Of Science
- Biochemistry
- Molecular Biology
- Oncology
Background
- Protein palmitoylation, a reversible lipid modification, involves attaching palmitic acid to cysteine residues.
- This modification impacts protein hydrophobicity, membrane localization, stability, and function.
- Palmitoylation is increasingly recognized for its significant role in cancer development and progression.
Purpose Of The Study
- To conduct a systematic bibliometric analysis of research on protein palmitoylation and cancer.
- To identify publication trends, research hotspots, and collaboration networks in this field.
- To assess the dynamics of scientific inquiry into protein palmitoylation in cancer biology.
Main Methods
- Systematic bibliometric analysis using the Web of Science Core Collection (WoSCC).
- Selection of 685 papers published between 2004 and 2024.
- Extraction and analysis of publication data, including titles, abstracts, and keywords.
Main Results
- A total of 685 papers were published on protein palmitoylation and cancer from 2004 to 2024, with a notable increase post-2020.
- The United States and China are leading countries, with Harvard University and the Chinese Academy of Sciences as key institutions.
- Research focus has shifted towards cancer-specific applications, including tumor immune evasion, metabolic reprogramming, and therapeutic strategies.
Conclusions
- Future research should prioritize creating pan-cancer palmitoylation site maps for subtype-specific patterns.
- Development of subtype-selective inhibitors targeting ZDHHC enzymes is crucial to overcome current toxicity issues.
- Establishing international research collaborations can bridge basic research and clinical innovation for precision therapeutics.
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