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Progress in the treatment of subarterial ventricular septal defect

Chunqiu Fan1, Zhengxia Pan1, Chun Wu1

  • 1Department of Cardio-Thoracic Surgery Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing Key Laboratory of Pediatrics Chongqing China.

Pediatric Discovery
|July 8, 2025
PubMed

Insights

Doubly committed ventricular septal defect (dcVSD) in children often requires timely intervention due to potential aortic valve issues and low self-healing rates. Current interventional methods are limited, making surgical approaches essential for effective treatment.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease
  • Cardiac Surgery

Background:

  • Ventricular septal defect is the most common congenital heart disease in children.
  • Doubly committed ventricular septal defect (dcVSD) presents unique anatomical challenges, often leading to early aortic valve lesions.
  • dcVSD has a low spontaneous closure rate, necessitating prompt medical or surgical intervention.

Purpose of the Study:

  • To summarize current treatment strategies for doubly committed ventricular septal defect (dcVSD).
  • To review the indications, surgical experience, and prognosis associated with dcVSD treatment.
  • To highlight the limitations of current interventional approaches for dcVSD.

Main Methods:

  • Review of existing literature on dcVSD treatment.
  • Analysis of surgical outcomes and patient prognoses.
  • Comparison of interventional versus surgical treatment modalities.

Main Results:

  • Interventional treatment via femoral vein is technically challenging with limited application for dcVSD.
  • Extracorporeal bypass and transthoracic occlusion are the primary surgical methods for dcVSD.
  • Surgical outcomes and prognosis depend on surgical experience and specific patient factors.

Conclusions:

  • Timely treatment is crucial for dcVSD due to its association with aortic valve lesions and low self-healing potential.
  • Surgical intervention remains the mainstay for dcVSD, despite ongoing advancements in interventional cardiology.
  • Further research into optimizing surgical techniques and patient selection for dcVSD is warranted.

Keywords:
cardiopulmonary bypassdoubly committed subarterial ventricular septal defectminimally invasive closure

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