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Optic nerve dysfunction during gravity inversion. Pattern reversal visual evoked potentials.

T R Friberg, G Sanborn

Archives of Ophthalmology (Chicago, Ill. : 1960)

|November 1, 1985

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Head-down positions significantly reduce visual evoked potentials (VEPs) due to increased intraocular pressure (IOP). This suggests gravity inversion activities pose risks to optic nerve function.

Area of Science:

Ophthalmology
Neuroscience
Human Physiology

Background:

Intraocular pressure (IOP) doubles in humans assuming a head-down position.
Ophthalmic artery pressure also increases, but the effect on optic nerve function is unclear.

Purpose of the Study:

To investigate the impact of head-down position and elevated IOP on optic nerve function.
To compare the effects of gravity inversion versus artificially elevated IOP on visual evoked potentials.

Main Methods:

Pattern reversal visual evoked potentials (PRVEPs) were recorded in 16 subjects in upright and inverted positions.
A separate experiment involved artificially increasing IOP using a scleral suction cup to mimic inversion IOP levels.

Main Results:

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PRVEP amplitudes were significantly reduced in both inverted and artificially elevated IOP conditions compared to controls.
Amplitude reduction was greater during gravity inversion than with suction cup elevation.
No significant changes in PRVEP latency or waveform were observed.

Conclusions:

Optic nerve function, as measured by PRVEPs, is primarily affected by intraocular pressure, not vascular perfusion changes.
Gravity inversion activities carry potential risks to ocular health due to elevated IOP.