Related Experiment Video
Updated: May 6, 2026
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
Plant-Derived Natural Products Ameliorating Hypertension via Signaling Pathways: A Review
Yushen Feng1,2,3, Juan Zhou1, Min Zhong1
1Anhui Province Key Laboratory of Non-Coding RNA Basic and Clinical Transformation (Wannan Medical College), Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China.
Insights
Natural products show promise for managing hypertension, a widespread condition affecting over a billion people. Research highlights flavonoids, terpenoids, and alkaloids as potential antihypertensive agents targeting key disease pathways.
Area of Science:
- Pharmacology and Natural Product Chemistry
- Cardiovascular Disease Research
- Integrative Medicine
Background:
- Hypertension affects over one billion people globally, increasing cardiovascular disease risk.
- Essential arterial hypertension is a major risk factor for stroke, renal failure, cardiac hypertrophy, and heart failure.
- Existing antihypertensive drugs are insufficient for many patients, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review natural products (NPs) with potential antihypertensive activities published between 2019 and 2024.
- To identify and categorize NPs targeting key hypertension pathogenesis pathways.
- To assess the potential of NPs as a source for novel antihypertensive agents.
Main Methods:
- Systematic literature search of PubMed and Web of Science databases.
- Inclusion of studies on NPs with antihypertensive potential published from 2019 to 2024.
- Categorization of identified NPs based on structural frameworks (flavonoids, terpenoids, alkaloids, plant extracts).
Main Results:
- Seventy unique natural products with potential antihypertensive activity were identified.
- NPs were classified into flavonoids (20), terpenoids (24), alkaloids (17), and plant-derived extracts (9).
- These compounds target pathways including oxidative stress, inflammation, vascular remodeling, and neurohormonal signaling.
Conclusions:
- Natural products offer a promising avenue for developing new antihypertensive therapies.
- Future research should focus on NPs with dual antioxidant/anti-inflammatory properties and improved delivery systems.
- Interdisciplinary approaches, including synthetic biology, are crucial for scalable NP production.
Abstract:
More than one billion people worldwide suffer from hypertension, and essential arterial hypertension is in particular a major risk factor for cardiovascular diseases. These conditions can lead to complications such as stroke, renal failure, cardiac hypertrophy, and heart failure. Despite extensive research on various antihypertensive drugs, an increasing number of people are unable to effectively control their hypertension. Further optimization of their treatment is required. Given the pathogenesis of hypertension, natural products (NPs) have emerged as a promising source of potential antihypertensive agents. NPs can prevent the development of hypertension by targeting oxidative stress, inflammation, vascular remodeling, and neurohormonal pathways. These targets provide the foundation for the application of NPs in clinical treatment. This review assesses NPs with potential antihypertensive activities published between 2019 and 2024. A total of 70 unique NPs were identified through PubMed and Web of Science. Seventy unique NPs were categorized into flavonoids (20 compounds), terpenoids (24 compounds), alkaloids (17 compounds), and plant-derived extracts (9 species). These products were classified according to their structural frameworks, and their bioactivities were briefly summarized. Future research should prioritize NPs with dual anti-oxidant/anti-inflammatory properties for clinical experiments, advanced delivery systems for improved bioavailability, and interdisciplinary approaches integrating synthetic biology for scalable production.
More Related Videos
Related Concept Videos
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
01:25Antihypertensive Drugs: Direct Renin Inhibitors
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
01:18Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
01:17Hormonal Regulation of Blood Pressure
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
01:29Hypertension II: Pathophysiology