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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

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Published on: August 25, 2014

Prenatal Exposure to Methamphetamine and Its Association With Birth Outcomes: A Meta-Analysis.

Nima Rastegar-Pouyani¹, Fatemeh Fakhari¹, Armineh Rezagholi Lalani²

¹Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Birth Defects Research

|July 8, 2025

Summary

Prenatal methamphetamine exposure significantly increases the risk of preterm birth (PTB), low birth weight (LBW), and being small for gestational age (SGA). This systematic review highlights critical public health concerns regarding substance use during pregnancy.

Keywords:

birth defects low birth weight meta‐analysis methamphetamine prenatal exposure preterm birth small for gestational age

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Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

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Published on: December 14, 2014

Area of Science:

Public Health
Perinatal Medicine
Toxicology

Background:

Methamphetamine abuse is a growing global public health concern.
Prenatal exposure to methamphetamine poses significant risks to fetal development and newborn health.

Purpose of the Study:

To systematically review and meta-analyze the association between prenatal methamphetamine exposure and adverse birth outcomes.
To evaluate risks for Preterm Birth (PTB), Low Birth Weight (LBW), and Small for Gestational Age (SGA).

Main Methods:

Systematic literature search of PubMed, Web of Science, and Scopus (up to Dec 2021).
Meta-analysis of eight observational studies using Odds Ratios (OR) and 95% Confidence Intervals (CI).
Assessed heterogeneity, publication bias, and performed sensitivity analysis.

Main Results:

Prenatal methamphetamine exposure is associated with a 2.64 times higher risk of PTB (OR 2.64; 95% CI 1.89-3.70).
Associated with a 2.83 times higher risk of LBW (OR 2.83; 95% CI 1.09-7.38).
Associated with a 1.44 times higher risk of SGA (OR 1.44; 95% CI 1.04-1.99).

Conclusions:

A substantial association exists between prenatal methamphetamine exposure and PTB, LBW, and SGA.
Findings underscore the critical need for interventions addressing prenatal methamphetamine use.