Facial Burn Healing With a Polylactic Acid Dermal Matrix: A Case Report on Wound Modulation and Graft-Free...

Area of Science:

• Regenerative Medicine
• Wound Healing
• Biomaterials

Background:

• Facial burns, particularly alkali burns, present complex challenges due to deep tissue necrosis and scarring.
• Current treatments like autografting have limitations including donor site morbidity and aesthetic concerns.

Purpose of the Study:

• To evaluate the efficacy of a synthetic polylactic acid (PLA)-based dermal matrix (SUPRA SDRM®) in managing deep alkali facial burns.
• To assess the matrix's role in wound healing, vascularization, and epithelialization as an alternative to autografting.

Main Methods:

• A case report of a 53-year-old male with deep alkali facial burns treated with SUPRA SDRM®.
• Application of the matrix as a wound barrier, monitoring for pain relief, vascularization, and epithelialization.
• Histological analysis and infrared thermography (IRT) imaging to assess tissue response and perfusion.

Main Results:

• SUPRA SDRM® provided rapid pain relief and promoted early vascularization.
• The matrix facilitated complete epithelialization within five weeks without requiring autografting.
• Histology showed enhanced angiogenesis and dermal remodeling; IRT suggested improved perfusion.

Conclusions:

• Polylactic acid (PLA)-based dermal matrices may offer a viable alternative to autografting for select deep burn injuries.
• SUPRA SDRM® demonstrated potential in modulating the wound environment and promoting functional healing.
• Further research is warranted to explore its application in burn care, especially in resource-limited settings.