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Complement C8 deficiency with recurrent meningococcemia: examination of meningococcal opsonization
Australian Paediatric Journal
|August 1, 1985
Summary
A child with recurrent fevers had a Neisseria meningitidis infection due to a deficiency in complement component 8 (C8) activity. Despite lacking functional C8, her serum showed normal opsonic activity against the bacteria.
Area of Science:
- Immunology
- Microbiology
- Pediatrics
Background:
- Recurrent febrile episodes in children can indicate underlying immune deficiencies.
- Neisseria meningitidis infections are serious and can be recurrent in immunocompromised individuals.
- Complement system deficiencies predispose individuals to invasive bacterial infections.