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Mycotoxins as carcinogens.

A M Hussain

    Basic Life Sciences
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Food and feed contamination by fungi can produce toxic mycotoxins, posing health risks. Aflatoxins, primarily from Aspergillus species, are a significant concern due to their carcinogenic potential in humans and animals.

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    Area of Science:

    • Food safety and mycology.
    • Toxicology and public health.

    Background:

    • Fungi contaminating food and feed produce toxic metabolites, creating health hazards.
    • Mycotoxins, including aflatoxins, are a significant concern in the food supply chain.

    Purpose of the Study:

    • To review the production and health implications of mycotoxins, with a focus on aflatoxins.
    • To highlight the primary fungal sources and routes of human exposure to mycotoxins.

    Main Methods:

    • Literature review on fungal contamination, mycotoxin production, and toxicity.
    • Analysis of factors influencing mycotoxin toxicity and carcinogenic potential.

    Main Results:

    • Aspergillus flavus and Aspergillus parasiticus are major sources of aflatoxins.

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  • Mycotoxins are ingested through contaminated food and animal products.
  • Toxicity is influenced by host factors (species, age, sex, nutrition).

    • Conclusions:

    • Most mycotoxins are carcinogenic, posing a serious health risk.
    • Controlling fungal contamination is crucial for food and feed safety.