Related Experiment Video
Updated: Sep 16, 2025
An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
Metabolic dysfunction, cirrhosis, and HCV genotype 3a drive type 2 diabetes risk in chronic hepatitis C: a Southern
Zhanyi Li1, Yuyu Ye1, Yeqiong Zhang1
1Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510000, Guangdong Province, China.
Background:
Chronic hepatitis C (CHC) is associated with an increased risk of type 2 diabetes mellitus (T2DM). However, regional variations in HCV genotypes and clinical characteristics may influence this association. This study aimed to investigate the association between chronic hepatitis C virus (CHC) infection and the development of T2DM in CHC patients in Southern China.
Methods:
A retrospective case-control cohort study analyzed 442 CHC patients (242 without T2DM, 200 with T2DM) from 2010 to 2018. Biochemical parameters, HCV genotypes, and clinical characteristics were compared. Multivariate logistic regression and ROC analysis were performed to evaluate predictors of T2DM.
Results:
The CHC + T2DM group exhibited significantly higher age (P < 0.001), BMI (P = 0.001), fasting blood glucose (P < 0.001), fasting insulin (P = 0.015), HOMA-IR (Homeostasis Model Assessment-Insulin Resistance) index (P < 0.001), transaminases alanine transaminase (ALT) (P < 0.001) and aspartate transaminase (AST) (P < 0.001), total bilirubin (P < 0.001), γ-Glutamyl Transferase (GGT) (P < 0.001), and cirrhosis prevalence (P < 0.001). Logistic regression analysis showed that age (OR: 1.09), fasting blood glucose (OR: 16.20), fasting insulin (OR: 1.23), HOMA-IR (OR: 0.48), and GGT (OR: 1.01), cirrhosis (OR: 15.32) and hypertension (OR: 31.00) were the risk factors of T2DM in CHC patients. HCV genotype distribution differed significantly between CHC and CHC + DM groups (P = 0.008), with genotype 3a more prevalent in CHC + DM (2.07% vs. 11.36%, P = 0.032). Receiver Operating Characteristic curve analysis highlighted fasting glucose (AUC = 0.904) as the strongest predictor.
Conclusion:
Age, metabolic dysregulation, liver cirrhosis, hypertension, and HCV genotype 3a are key risk factors for T2DM in CHC patients. Early screening for glucose intolerance and genotype-specific interventions are critical in high-risk populations.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
01:36Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
01:19Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
01:22Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
01:30Coronary Artery Disease I: Introduction