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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Obsessive-compulsive disorder in the World Mental Health surveys
Dan J Stein1, Ayelet Meron Ruscio2, Yasmin Altwaijri3
1SAMRC Unit On Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa. dan.stein@uct.ac.za.
Obsessive-compulsive disorder (OCD) affects 4.1% globally, often starting in early adulthood and frequently remaining untreated, especially in lower-income nations. Early diagnosis and comorbidity assessment are crucial for public health.
Area of Science:
- Global Mental Health
- Psychiatry
- Epidemiology
Background:
- Obsessive-compulsive disorder (OCD) is recognized as prevalent and impairing.
- Cross-national data on OCD prevalence, course, and treatment remain scarce, particularly in low- and middle-income countries (LMICs).
Purpose of the Study:
- To characterize the onset, course, severity, and treatment of OCD across diverse global regions.
- To investigate predictors of OCD onset, persistence, severity, and treatment.
Main Methods:
- Utilized data from World Mental Health surveys in 10 countries (6 high-income, 4 LMICs).
- Assessed 26,136 adults via face-to-face interviews for lifetime and 12-month prevalence, age of onset, persistence, severity (Yale-Brown Obsessive-Compulsive Scale), and treatment.
- Examined socio-demographic variables and prior mental disorders as potential predictors.
Main Results:
- Combined lifetime OCD prevalence was 4.1%, with a 12-month prevalence of 3.0%, indicating persistence.
- Onset typically occurs in adolescence or early adulthood; most cases are mild to moderate.
- Only 19.8% received treatment, significantly lower in LMICs (7.0%) compared to high-income countries (HICs) (40.5%).
Conclusions:
- OCD is a significant public health concern, often overlooked and undertreated globally.
- Early diagnosis and comprehensive comorbidity evaluation are critical clinical strategies.
- Addressing treatment disparities in LMICs is essential for improving global OCD outcomes.
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